Background/Aim: Autologous platelet-derived growth factors such as platelet rich fibrin (PRF) are receiving increasing attention in the context of different medical situations such as soft-tissue wound healing or bone regeneration in patients with cancer suffering from therapy-associated osteonecrosis. PRF has been observed to support the colonization and differentiation of osteoblasts, thereby improving the wound healing process. In the recent past, fruit extracts from the tropical plant Morinda citrifolia have been associated with improved intestinal health and anti-inflammatory therapeutic effects. The aim of this study was to investigate the influence of Morinda citrifolia-derived noni juice on clinical blood parameters and the composition of human PRF.

Materials and Methods: Forty healthy volunteers participated in a prospective, single-blinded, placebo-controlled, cross-over study. Participants consumed either noni juice (2 ml/kg/day) or placebo for four weeks, separated by a four-week washout. Blood samples were collected, and PRF was prepared by centrifugation. Clinical blood values were analyzed, and PRF samples were examined for growth factors, structural proteins, and cytokines using ELISA and cytokine arrays.

Results: Noni juice consumption led to significant changes in blood calcium, ALAT, and γ-GT levels. PRF analysis revealed elevated interleukin-11 (IL-11), macrophage colony-stimulating factor (M-CSF), and chemokine CCL7, indicating that noni juice alters the molecular profile of PRF.

Conclusion: Regular intake of noni juice influences PRF composition and modulates hepatic enzymes. These findings highlight the potential of dietary factors to impact regenerative biomaterials and warrant further targeted investigations.

This article is published in the Journal "In Vivo" (2026).